Preimplantation Genetic Testing in ARTs

At Mamata Fertility Hospital in Secunderabad, we bring together compassionate care and cutting-edge technology to offer the best solutions to couples on their fertility journey. Preimplantation Genetic Testing (PGT) is an advanced tool in Assisted Reproductive Technologies (ARTs) that enables us to enhance the success of treatments like IVF (in vitro fertilization) and ICSI (Intracytoplasmic Sperm Injection). PGT represents a new frontier in fertility care, allowing for better outcomes, healthier pregnancies, and peace of mind for aspiring parents.

What is Preimplantation Genetic Testing (PGT)?

Preimplantation Genetic Testing, or PGT, is a highly advanced procedure performed during ART cycles to evaluate the genetic makeup of embryos. By examining embryos for abnormalities in their chromosomes or genetic markers, PGT helps identify embryos most likely to result in a successful and healthy pregnancy.

Through careful genetic screening, PGT allows doctors to:

• Detect potential genetic disorders.
• Assess overall embryo health.
• Select the most viable embryos for implantation.

At Mamata Fertility Hospital, we use PGT as part of our commitment to offering groundbreaking fertility care that puts the health and future of both parents and baby first.

Types of PGT

PGT is divided into three main types, each suited to specific medical needs.

1. PGT-A (Preimplantation Genetic Testing for Aneuploidy)

PGT-A screens embryos for chromosomal abnormalities, such as missing or extra chromosomes, which can lead to failed implantation or conditions like Down syndrome.

• Who Benefits? Patients with recurrent IVF failures, advanced maternal age, or a history of miscarriage.
• Purpose: Improves implantation chances by selecting chromosomally healthy embryos.

2. PGT-M (Preimplantation Genetic Testing for Monogenic Disorders)

PGT-M identifies embryos affected by specific genetic conditions that are inherited from parents.

• Who Benefits? Couples with a family history of genetic disorders like cystic fibrosis, thalassemia, or Huntington’s disease.
• Purpose: Prevents the transmission of genetic disorders to the child.

3. PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements)

PGT-SR examines embryos for structural abnormalities in chromosomes, such as translocations or inversions, which can lead to pregnancy loss or genetic conditions in offspring.

• Who Benefits? Patients with known chromosomal rearrangements or unexplained infertility.
• Purpose: Reduces the risk of miscarriage by selecting embryos with balanced chromosomes.

At Mamata Fertility Hospital, we personalize PGT recommendations based on your unique situation to ensure optimal outcomes.

How PGT Works in ARTs?

PGT is integrated seamlessly into the IVF or ICSI process to provide an enhanced level of precision. Here’s how it works step-by-step:

1. Ovulation Stimulation and Egg Retrieval: Fertility medication is used to stimulate the ovaries, and mature eggs are collected via a minor procedure.
2. Fertilization (IVF/ICSI): The eggs are fertilized in the lab using sperm from the male partner or donor.
3. Embryo Development: Fertilized embryos are cultured in a laboratory setting for 5-7 days until they reach the blastocyst stage.
4. Biopsy: A few cells are carefully removed from each blastocyst (embryo) without causing harm to its development.
5. Genetic Testing: The sampled cells are sent to a specialized genetics lab, where their DNA is analyzed for chromosomal abnormalities or genetic disorders.
6. Results and Embryo Selection: Based on the PGT results, the healthiest and most viable embryos are selected for implantation into the uterus.
7. Frozen Embryo Transfer (FET): Healthy embryos may be transferred during a subsequent IVF cycle, allowing time for results and uterine preparation.

PGT gives couples a significant edge in ART treatments, by identifying embryos most likely to result in a healthy and successful pregnancy.

Benefits of PGT in IVF/ICSI

Choosing PGT as part of your IVF or ICSI cycle offers several advantages to improve your chances of success and ensure a healthy pregnancy.

Key Benefits:

• Improved Success Rates: By transferring genetically healthy embryos, PGT increases the likelihood of implantation and live birth rates.
• Reduced Risk of Genetic Disorders: It helps prevent hereditary conditions from being passed to the next generation.
• Fewer Miscarriages: By identifying and eliminating embryos with chromosomal abnormalities, PGT reduces miscarriages caused by aneuploidy.
• Single Embryo Transfer: Instead of transferring multiple embryos, PGT supports the selection of a single healthy embryo, minimizing risks like multiple pregnancies.
• Peace of Mind: Knowing that your embryo is healthy allows for a more confident and stress-free pregnancy.

At Mamata Fertility Hospital in Secunderabad, we have seen countless patients benefit from PGT’s ability to combine technology and care for better outcomes.

Who Should Consider PGT?

PGT isn’t necessary for every ART cycle but is particularly beneficial for specific patient profiles.

You may benefit from PGT if you:

• Are over 35 years of age and trying to conceive.
• Have experienced recurrent miscarriages or failed IVF cycles.
• Have a known family history of genetic conditions.
• Are carriers of genetic conditions like thalassemia or sickle cell anemia.
• Have concerns about passing on a chromosomal rearrangement due to a known balanced translocation.
• Prefer a single embryo transfer but want to maximize pregnancy success rates.

Our experienced specialists will review your medical history, test results, and concerns before recommending PGT as part of your ART treatment plan.

Success Rates and Accuracy of PGT

How Accurate is PGT?

PGT utilizes state-of-the-art genetic testing techniques like Next-Generation Sequencing (NGS), ensuring a high level of accuracy in determining embryo health. At Mamata Fertility Hospital, our PGT process adheres to the highest standards for reliable and trustworthy results. Accuracy rates for PGT are typically above 98%, making it a valuable tool for embryo selection.

Impact on Success Rates

Research shows that PGT can significantly improve IVF success rates by maximizing the odds of healthy pregnancies. Healthy embryos selected using PGT are more likely to implant successfully, leading to a higher rate of live births.

Our success rates for patients using PGT in Secunderabad reflect the combination of skill, technology, and personalized care offered at our hospital.

Ethical Considerations

Balancing Technology with Ethics

While PGT provides immense benefits, it also raises ethical questions that deserve careful consideration.

• Decision-Making: While PGT can identify abnormalities, it’s the couple’s choice to decide what action to take.
• Eugenics Debate: It’s important to use the technology responsibly, avoiding misuse for non-medical preferences like gender selection where it’s not legally or ethically permissible.

At Mamata Fertility Hospital, our team ensures that PGT is used ethically and exclusively to facilitate healthy pregnancies or address genuine medical concerns.

Why Choose Mamata Fertility Hospital for PGT in Secunderabad?

When it comes to fertility diagnostics and treatments like Preimplantation Genetic Testing in Secunderabad, Mamata Fertility Hospital stands out as a trusted name in individualized care.

Here’s why we’re the preferred choice for PGT services:

1. Experienced Specialists: Our fertility experts have extensive experience with PGT and handle even the most complex cases with expertise.
2. Advanced Technology: We utilize cutting-edge tools including Next-Generation Sequencing (NGS) to ensure the highest standards of genetic testing.
3. Comprehensive Care: Our teams provide end-to-end support, from IVF/ICSI treatment to PGT procedures and personalized counseling.
4. Focus on Patient Comfort: Your health and peace of mind are at the center of everything we do, creating a stress-free and supportive environment.
5. Proven Success: Our high success rates reflect our commitment to delivering results tailored to each couple’s unique needs.

Take the next step in your fertility journey with the expert guidance and unmatched care offered at Mamata Fertility Hospital.

Whether you’re considering IVF, ICSI, or PGT for the first time, our team is here to guide you with the latest in science and a compassionate approach to care. Schedule your consultation today to explore how Preimplantation Genetic Testing in Secunderabad can enhance your chances of a successful pregnancy and a healthy family!