PGT-SR (Preimplantation Genetic ing for Structural Rearrangements)

At Mamata Fertility Hospital in Secunderabad, we are committed to providing clarity and precision in your IVF treatment to ensure the best possible outcomes. 

One of the advanced technologies revolutionizing fertility care is PGT-SR (Preimplantation Genetic Testing for Structural Rearrangements). This specialized genetic test is designed to detect chromosomal structural abnormalities in embryos during the IVF process. 

PGT-SR enables the safe transfer of chromosomally balanced embryos, ensuring reduced risks of implantation failure, miscarriage, or genetic disorders in the child.

With our expertise in chromosomal rearrangement testing for IVF in Secunderabad, we help individuals and couples identify the healthiest embryos, offering a greater chance of achieving successful pregnancy outcomes. 

If you’re seeking advanced solutions in your fertility journey, PGT-SR could be the key to your success.

What is PGT-SR & Purpose of This Test?

PGT-SR, or Preimplantation Genetic Testing for Structural Rearrangements, is a genetic screening method used in IVF to analyze embryos for abnormal structural changes in chromosomes. 

Structural rearrangements include instances where segments of chromosomes are misplaced, inverted, duplicated, or deleted. These abnormalities can lead to failed implantation, miscarriages, or chromosomal imbalances in offspring that may result in developmental or health issues.

PGT-SR examines embryos during the IVF process to identify those with normal chromosomal structure, thereby increasing the likelihood of successful pregnancy and reducing genetic risks for the baby.

Purpose of PGT-SR:

• Identify Balanced Embryos: Detect embryos free of chromosomal rearrangements to ensure successful implantation.
• Improve Pregnancy Outcomes: Increase the chances of delivering a healthy baby by selecting chromosomally normal embryos.
• Reduce Miscarriage Risks: Minimize risks associated with embryos carrying structural imbalances.
• Manage Known Chromosomal Risks: Help couples with a history of structural rearrangements or genetic conditions.
• Support Single-Embryo Transfer: Aid in selecting a high-quality embryo for implantation, reducing risks of multiple pregnancies.

At Mamata Fertility Hospital, we employ cutting-edge technologies to conduct advanced genetic testing for embryos, ensuring the process is precise, effective, and deeply personalized to your needs.

Who Should Consider This Test? (Eligibility and Scenarios)

PGT-SR is a highly specialized test designed for specific situations and conditions. Families with a risk of chromosomal structural abnormalities are the primary beneficiaries, although it can provide value in other challenging IVF scenarios as well.

Who is Eligible for PGT-SR?

1. Carriers of Chromosomal Rearrangements: Individuals or couples with a known history of chromosomal rearrangements such as translocations or inversions.
2. Repeated IVF Failures: Couples experiencing multiple unsuccessful IVF cycles may benefit from screening for structural abnormalities in embryos.
3. History of Miscarriage: PGT-SR can help couples with recurrent pregnancy loss caused by genetic irregularities.
4. Pregnancies with Chromosomal Imbalances: Families with prior pregnancies affected by chromosomal abnormalities may seek safer IVF solutions.
5. Male Factor Infertility Cases: Severe sperm abnormalities, such as high DNA fragmentation, may contribute to structural issues in embryos.

Scenarios for Choosing PGT-SR:

• A couple with reciprocal chromosomal translocations causing recurrent miscarriages.
• Individuals with a personal or family history of chromosomal conditions, such as deletions or duplications.
• Patients facing repeated IVF failures despite optimal fertility treatment.

If these scenarios resonate with your family’s circumstances, explore PGT-SR in Secunderabad at Mamata Fertility Hospital as a way to bring clarity and confidence to your fertility decisions.

How to Prepare for the Tests?

Preparation for PGT-SR is straightforward and follows the regular IVF protocol. The only adjustment is the integration of genetic testing in the process to evaluate embryo health.

Key Preparation Steps for PGT-SR:

1. Detailed Genetic Evaluation:
• Couples should discuss their medical and family history with our genetic counselors. If there are known chromosomal rearrangements, these will guide the testing process.
2. Complete Preliminary Screening:
• Routine fertility tests like hormone profiling, ovarian reserve assessments, semen analysis, and general health checks are essential for planning the IVF cycle.
3. Plan for Ovarian Stimulation:
• Prepare for fertility medications to stimulate egg production and ensure a good number of embryos for testing.
4. Focus on Physical and Emotional Health:
• A healthy lifestyle positively impacts egg, sperm, and embryo quality. Reduce stress with relaxation techniques, eat a balanced diet, and avoid alcohol or smoking.

At Mamata Fertility Hospital, we guide our patients step by step, answering questions and alleviating concerns to ensure you are prepared for chromosomal rearrangement testing for IVF.

How are the Tests Performed?

PGT-SR is seamlessly integrated into the IVF and embryo transfer process, relying on sophisticated laboratory techniques to ensure the most accurate screening.

Step-By-Step Process for PGT-SR Testing:

1. IVF Procedure:
• Begin with ovarian stimulation, egg retrieval, and fertilization to create embryos in the laboratory.
2. Blastocyst Development:
• Embryos are cultured and monitored for 5–6 days until they reach the blastocyst stage, which is ideal for genetic testing.
3. Biopsy of Embryos:
• A small number of cells are gently taken from the embryo’s outer layer (trophectoderm) without affecting its core. The embryo is then frozen for preservation.
4. Genetic Testing Analysis:
• Biopsied cells are analyzed to examine the chromosomes and determine whether structural rearrangements or imbalances are present.
5. Transfer Planning:
• Based on the test results, only chromosomally stable embryos are selected for transfer in the next cycle.

With our expertise and advanced technology in PGT-SR in Secunderabad, this process ensures that every step is precise and non-invasive, prioritizing embryo health.

Ask Yourself These Questions to Know If You Need These Tests

1. Do you or your partner have a family history of chromosomal rearrangements or related issues?
2. Have you experienced multiple miscarriages or implantation failures?
3. Are you looking to reduce genetic risks in your child and ensure a healthy pregnancy?
4. Are you over 35, where chromosomal risks increase?
5. Do you want to optimize embryo selection for single-embryo transfer?

If you answered “yes,” consider PGT-SR in Secunderabad with Mamata Fertility Hospital as a valuable step in your fertility plan.

What Will Be Included in the Test Report?

The PGT-SR test report is a comprehensive analysis that provides detailed insights into the chromosomal health of your embryos. It serves as the foundation for making informed decisions about future fertility treatments.

Key Report Details:

1. Chromosomal Structure Assessment: Whether each embryo is balanced (normal chromosomal structure), unbalanced (with rearrangements), or mosaic.
2. Type of Aberration: Identification of issues like translocations, deletions, inversions, or duplications.
3. Transfer Advice: Guidance on which embryo offers the best chances for successful implantation and pregnancy.
4. Further Testing Recommendations: If needed, referral for additional evaluations or consultations with specialists.

Our experts at Mamata Fertility Hospital will take the time to explain the results in detail, ensuring you feel confident and fully informed at every stage

How Can This Test Help You Make Informed Decisions?

PGT-SR empowers families by providing critical insights into the genetic viability of embryos. It reduces risks, improves success rates, and enables targeted, informed decision-making.

Benefits of PGT-SR:

1. Increase Pregnancy Success Rates: Verify embryos for chromosomal balance before implantation to improve outcomes.
2. Reduce Risk of Miscarriages: Identify imbalances that lead to recurrent loss, ensuring only stable embryos are transferred.
3. Prevent Genetic Disorders: Avoid developmental challenges caused by inherited chromosomal rearrangements.
4. Optimize Single-Embryo Transfer: Enhance the likelihood of success with the first transfer, reducing the need for repeated cycles.
5. Reassure Future Family Plans: Test and preserve healthy embryos for potential future pregnancies.

At Mamata Fertility Hospital, our advanced genetic testing for embryos ensures your treatment is guided by scientific precision.

Why Choose Mamata Fertility Hospital for PGT-SR?

At Mamata Fertility Hospital, we pride ourselves on leading technologies and compassionate, patient-first care.

Why Patients Trust Us:

• Advanced Expertise: Our specialists are leaders in genetic testing and embryo analysis.
• Cutting-Edge Tools: We use the latest methods to ensure accurate results and reliable insights.
• Personalized Treatment Plans: Tailored options to fit your fertility requirements.
• Transparent Pricing: Clear and affordable costs with no hidden fees.
• Support at Every Step: A caring team dedicated to guiding you through this important process.

Take the next step with confidence. Book a consultation for PGT-SR in Secunderabad at Mamata Fertility Hospital today and ensure a brighter path to building your family.