PGT-A (Preimplantation Genetic ing for Aneuploidy)

At Mamata Fertility Hospital in Secunderabad, we are dedicated to making every step of your reproductive journey as informed and successful as possible. For couples undergoing IVF, one of the most critical factors in achieving a healthy pregnancy is the selection of viable embryos. 

This is where PGT-A (Preimplantation Genetic Testing for Aneuploidy) plays a vital role. By identifying chromosomal abnormalities in embryos, PGT-A enhances the likelihood of implantation and minimizes the risks of implantation failure or miscarriage.

With our cutting-edge technology and personalized care, we are leaders in chromosomal screening for IVF in Secunderabad. 

Whether you are just starting your fertility treatment or have experienced challenges in the past, PGT-A provides clarity and confidence in planning your next steps.

What is PGT-A & Purpose of This Test?

PGT-A, or Preimplantation Genetic Testing for Aneuploidy, is a genetic screening technique performed as part of an IVF cycle to assess embryos for chromosomal abnormalities. 

Aneuploidy occurs when an embryo has an abnormal number of chromosomes—either missing or having extra chromosomes—which can lead to failed implantation, miscarriage, or developmental disorders like Down syndrome.

PGT-A evaluates embryos’ chromosomal makeup before implantation so that only embryos with the correct number of chromosomes (euploid embryos) are selected for transfer. This process ensures a higher likelihood of achieving a successful pregnancy and delivering a healthy baby.

Purpose of PGT-A:

• Detect Chromosomal Abnormalities: Identify aneuploid embryos that may lead to pregnancy complications.
• Support Successful Implantation: Select euploid embryos, improving implantation rates.
• Minimize Miscarriage Risks: Reduce the likelihood of pregnancy loss due to chromosomal irregularities.
• Improve IVF Outcomes: Aid in achieving a successful pregnancy within fewer IVF cycles.
• Address Age-Related Risks: Help older women or those with specific concerns about chromosomal health.

At Mamata Fertility Hospital, our expertise in advanced genetic testing for embryos allows us to deliver highly accurate and reliable results for the best possible outcomes.

Who Should Consider This Test? (Eligibility and Scenarios)

PGT-A is especially beneficial for individuals or couples in certain categories where chromosomal abnormalities are more likely to occur or could pose significant risks.

Who is Eligible for PGT-A?

1. Couples with Repeated IVF Failures: If previous IVF cycles have resulted in failed implantation, PGT-A may identify chromosomal issues in embryos.
2. Women of Advanced Maternal Age: Women aged 35 and above are at a higher risk of chromosomal abnormalities in their eggs, making PGT-A particularly valuable.
3. History of Pregnancy Loss: Couples with a history of multiple miscarriages may use PGT-A to reduce the risk of future losses.
4. Carriers of Chromosomal Disorders: Those with known chromosomal translocations or genetic abnormalities in the family can benefit from this test.
5. Male Factor Infertility Cases: Couples dealing with severe sperm abnormalities or DNA fragmentation may use PGT-A to ensure embryo viability.

Scenarios for Choosing PGT-A Testing:

• An older couple pursuing IVF and concerned about chromosomal abnormalities related to age.
• Patients who have faced recurrent pregnancy loss and wish to reduce future risks.
• Families aiming for a healthy singleton pregnancy through single-embryo transfer.

If any of these scenarios apply to you, consider PGT-A in Secunderabad at Mamata Fertility Hospital to make more informed reproductive choices.

How to Prepare for the Tests?

Preparing for PGT-A involves the same steps as any other IVF procedure, as the genetic testing is an integrated part of the overall cycle.

Preparation Guidelines for PGT-A Testing:

1. Comprehensive Fertility Evaluation:
• Both partners may need to undergo basic fertility tests, such as hormonal analysis, semen analysis, or ovarian reserve testing, to set the foundation for the IVF process.
2. Pre-IVF Counseling:
• Our fertility experts and genetic counselors will discuss the process of PGT-A in detail and review any genetic information relevant to your family history.
3. Ovarian Stimulation and Monitoring:
• Hormone injections will stimulate egg production, and regular monitoring ensures timely egg retrieval.
4. General Health Optimization:
• A healthy diet, regular exercise, and stress reduction can improve outcomes during the IVF and embryo testing process.

Our team at Mamata Fertility Hospital works diligently to ensure you are prepared for every stage of your chromosomal screening for IVF.

How are the Tests Performed?

PGT-A is seamlessly integrated into the IVF process, occurring after fertilized eggs develop into embryos but before implantation.

Step-by-Step PGT-A Process:

1. IVF Procedure Initiation:
• After ovulation stimulation and egg retrieval, eggs are fertilized with sperm in the laboratory to create embryos.
2. Blastocyst Development:
• Embryos are cultured in the lab for 5–6 days until they reach the blastocyst stage, when they have enough cells for testing.
3. Biopsy:
• A small number of cells are removed from the outer layer (trophectoderm) of the embryo. The embryo itself remains intact and is cryopreserved (frozen) to await the test results.
4. Chromosomal Analysis:
• The extracted cells undergo genetic testing to count chromosomes and identify aneuploid embryos.
5. Selection and Embryo Transfer:
• Based on the results, only chromosomally normal embryos are selected for transfer to maximize the chances of implantation.

This meticulous process ensures the best embryo is selected for transfer, providing a higher probability of achieving a successful pregnancy.

Ask Yourself These Questions to Know If You Need These Tests

1. Are you over 35 and concerned about chromosomal risks in embryos?
2. Have you experienced multiple IVF failures or miscarriages?
3. Are you concerned about passing on a family history of chromosomal abnormalities?
4. Do you want to optimize the success of a single-embryo transfer?
5. Are you looking to reduce IVF cycles by improving embryo selection?

If you answered “yes” to one or more of these questions, consider scheduling PGT-A testing with Mamata Fertility Hospital.

What Will Be Included in the Test Report?

Your PGT-A test report provides a detailed analysis of the chromosomal health of your embryos, serving as a guide for making informed decisions during the IVF process.

Key Details in the Report:

1. Chromosomal Result for Each Embryo: Information on whether each embryo is euploid (normal), aneuploid (abnormal), or mosaic (partially abnormal).
2. Abnormality Details: Identification of specific missing or extra chromosomes, if applicable.
3. Recommendations for Transfer: Guidance on which embryos are ideal for transfer based on chromosomal health and implantation potential.
4. Additional Insights: Considerations for freezing or further testing of embryos if required.

The detailed findings of the report will be explained by our team of fertility specialists, ensuring you fully understand their implications.

How Can This Test Help You Make Informed Decisions?

PGT-A empowers individuals and families by providing accurate insights into their embryos’ chromosomal health. This information can increase IVF success rates while reducing uncertainties and risks.

Key Benefits of PGT-A Testing:

1. Increase IVF Success Rates: Selecting chromosomally healthy embryos improves implantation chances within fewer cycles.
2. Reduce Miscarriage Risk: Prevent transferring embryos likely to result in unsuccessful pregnancies due to aneuploidies.
3. Single-Embryo Transfer (SET): Choose one high-quality embryo to reduce the risks associated with multiple pregnancies.
4. Avoid Genetic Disorders: Minimize the chances of passing on chromosomal abnormalities to offspring.
5. Plan for the Future: Freeze and preserve additional normal embryos for future family-building plans.

By offering state-of-the-art advanced genetic testing for embryos, Mamata Fertility Hospital enables you to make empowered choices throughout your IVF process.

Why Choose Mamata Fertility Hospital for PGT-A?

At Mamata Fertility Hospital in Secunderabad, we combine advanced genetic testing technology with patient-centric care to deliver outstanding outcomes for families.

Why Patients Trust Us:

• Innovative Techniques: Access leading-edge tools for accurate chromosomal screening.
• Experienced Specialists: Work with skilled embryologists and fertility experts who prioritize your success.
• Transparent Costs: We provide affordable and clear pricing options for our services.
• Compassionate Support: Empowering you with the knowledge and emotional support needed for your fertility decisions.

Take control of your fertility journey today. Schedule your appointment for PGT-A in Secunderabad at Mamata Fertility Hospital and take the next step toward a successful pregnancy with the confidence that comes from making informed choices.